Abstract
There have been many reports of SLE accompanied with circulating anticoagulant formation. However, biological and immunological characters of anticoagulant are not completely elucidated.This paper reports a child case of male SLE accompanied with circulating anticoagulant formation.Patient's plasma showed prolonged PT, PTT and recalcification time. Any of the clotting factors were not deficient, and screening test of anticoagulants using modified methods of PT, PTT and recalcification time revealed an anticoagulant in patient's plasma. Inhibitor against PF3 was not detected. Amounts of antithrombin III and α2-macroglobulin, natural inhibitor against activated factor X, were normal. Because of normal amount of clotting factors, the anticoagulant seemed to interfere with activated factor, especially activated factor X.Anticoagulant was detected in γ-globulin fraction of patient's serum separated by electrophoresis, and was neutralized by both anti-human IgG and IgA serum.
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