Abstract
Objective: To analyze the distribution characteristics and clinical significance of SLCO1B1 and ApoE gene polymorphisms of the Li people in Hainan Island. Method: Selecting 502 high school students of the Li people from five cities and counties in Hainan Island (namely, Qiongzhong County, Dongfang City, Ledong County, Baoting County and Wuzhishan City) as research subjects in September, 2019; Applying PCR-fluorescence probe method to detect SLCO1B1 and ApoE genotypes of the Li people in Hainan Island, and statistically analyzing the distribution characteristics of gene frequency and the distribution differences in gene polymorphisms between different genders. Meanwhile, detecting the SLCO1B1 and ApoE gene of 527 people from the Han people in five regions mentioned before, so as to analyze the distribution differences of the SLCO1B1 and ApoE gene between the Han people and the Li people. Results: The frequency of each genotype of SLCO1B1 in the Li people in Hainan Island is: *1a/*1a 6.77%, *1a/*1b 27.09%, *1b/1b 41.63%, *1a/*5 0.00%, *1a/*15 4.78%, *1b/15 16.93%., *5/*5 0.00%, *5/*15 0.00%, *15/*15 2.79%; And that of ApoE is: e2/e2 0.40%, e2/e3 17.73%, e2/e4 2.39%, e3/e3 65.54%, e3/e4 12.55%, e4/e4 1.39%. There is no significant difference (P > 0.05) in other genotypes except weak metabolic genotypes (*5/*5, *5/*15 and *15/*15) between the Han and the Li peoples. Conclusion: The gene frequency of SLCO1B1 weak metabolic genotype is dramatically higher in the Li people of Hainan Island than that of the Han people in both Hainan Island and Central and South China, but there is no significant difference in ApoE gene frequency among them. Therefore, clinicians should adjust the dosage of statins and select the types of lipid-lowering drugs according to the differences in patients’ genotypes, and strengthen the management of patients with ApoE4 risk gene.
Highlights
Statins, namely 3-hydroxy-3 methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are the most effective lipid-lowering drugs and have become the most effective drugs for the prevention and treatment of coronary heart disease
The χ2 test indicates that the gene frequency of SLCO1B1 and ApoE is conformed to the Hardy-Weinberg equilibrium (SLCO1B1 388A>G, 521T>C and ApoE 388T>C, 526C>T and P > 0.05), so the Li people selected in the study is representative
The χ2 test indicates that the gene frequency of SLCO1B1 and ApoE is conformed to the Hardy-Weinberg equilibrium (SLCO1B1 388A>G, 521T>C and ApoE 388T>C, 526C>T and P > 0.05), so the Han people selected in the study is representative
Summary
Statins, namely 3-hydroxy-3 methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are the most effective lipid-lowering drugs and have become the most effective drugs for the prevention and treatment of coronary heart disease. Different statins have the same functional group-hydroxyglutarate in chemical structure, the inheritance and variation of drug genes vary among individuals, especially affecting the coding gene of OATP1B1, SLCO1B1 and the SNP of ApoE’s coding gene in several aspects, such as their pharmacokinetics (absorption, binding to plasma proteins, metabolism, and solubility), interactions with other drugs, drug efficacy, and adverse effects and so on. These aspects will vary dramatically among different individuals [2]. It is important to conduct SLCO1B1 and APOE genotype testing to suggest the risk of adverse effects of statin use and to prevent cardiovascular and cerebrovascular disease, which can assist the clinicians to provide individualized medications for patients
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