Abstract
BackgroundNatural resistance associated macrophage protein 1 (NRAMP1), encoded by the SLC11A1 gene, has been described to regulate macrophage activation and be associated with infectious and autoimmune diseases. The relation between SLC11A1 polymorphisms and tuberculosis susceptibility has been studied in different populations.MethodsWe systematically reviewed published studies on SLC11A1 polymorphisms and tuberculosis susceptibility until September 15, 2010 and quantitatively summarized associations of the most widely studied polymorphisms using meta-analysis.ResultsIn total, 36 eligible articles were included in this review. In Meta-analysis, significant associations were observed between tuberculosis risk and widely studied SLC11A1 polymorphisms with summarized odds ratio of 1.35 (95%CI, 1.17–1.54), 1.25 (95% CI, 1.04–1.50), 1.23 (95% CI, 1.04–1.44), 1.31 (95%CI, 1.08–1.59) for 3′ UTR, D543N, INT4, and 5′ (GT)n, respectively. Heterogeneity between studies was not pronounced, and the associations did not remarkably vary in the stratified analysis with respect to study population and study base.ConclusionsThe association between SLC11A1 polymorphisms and tuberculosis susceptibility observed in our analyses supports the hypothesis that NRAMP1 might play an important role in the host defense to the development of tuberculosis.
Highlights
Host genetic susceptibility to infectious disease has been widely studied in recent years, which is helpful for high-risk population identification and promotes diseases prevention and early diagnosis [1,2]
Forty seven studies addressing the association of SLC11A1 polymorphisms and TB were identified, and full-text article retrieve excluded 11 of them
This review addressed the associations between SLC11A1 polymorphisms and TB susceptibility reported until September 2010
Summary
Host genetic susceptibility to infectious disease has been widely studied in recent years, which is helpful for high-risk population identification and promotes diseases prevention and early diagnosis [1,2]. Such study contributes to clarify potential mechanisms underlying host defense to the disease development. Natural resistance associated macrophage protein 1 (NRAMP1), encoded by the SLC11A1 gene, has multiple effects on macrophage activation and has been reported to play an important role in host innate immune response against infections [3]. In 1998, for the first time, relation between SLC11A1 polymorphisms and TB susceptibility was reported in a population from West Africa [7]. Natural resistance associated macrophage protein 1 (NRAMP1), encoded by the SLC11A1 gene, has been described to regulate macrophage activation and be associated with infectious and autoimmune diseases. The relation between SLC11A1 polymorphisms and tuberculosis susceptibility has been studied in different populations
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