Abstract
The lecture will summaries current standards of disease staging and treatment of Primary Central Nervous System Lymphoma (PCNSL). Concepts underlying the current first-line treatment regimen will be presented and current controversies in the treatment of PCNSL, including choice of induction regimen, choice of consolidation, and the roles of surgery/radiation/intrathecal therapy, will be discussed. In additional, the presentation will summarize novel insights into the pathophysiology of PCNSL, particularly the B-cell receptor signaling pathway (BCR). Results of completed and ongoing clinical trials targeting the BCR will be presented. The treatment standards in the recurrent setting will be summarized and additional novel therapeutic avenues, eg. immune checkpoint inhibition will be discussed. Furthermore, novel combinational clinical trials in recurrent/refractory setting will be discussed. Moreover, the diagnostic and prognostic value of novel, genomic testing and their integration into clinical trial development and clinical decision making will be discussed.
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