Abstract

DURING the examination of changes in the soluble sulphydryl content of mouse skin produced by application of polycyclic hydrocarbons it was noted that the result from a sample (pool of two animals) taken from a larger group occasionally differed significantly from the mean —SH for the larger group. The possibility existed that those animals the skin —SH of which differed from the mean were of different age or had skin with hair in more than one stage of growth. Consequently, untreated mouse skin from mice of varying age, sex, strains, and stage of hair cycle were used to investigate factors determining soluble sulphydryl content of mouse skin.

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