Abstract
The alarming increased incidence of skin cancers is closely related to ultraviolet radiation exposure, known to induce cellular transformation in epidermal and dermal layers. The current study describes the behavior of normal (human keratinocytes � HaCat and fibroblasts -1BR3) and tumor cells (human � A375 and murine � B164A5 and B16-F0 - melanoma) after UVB irradiation. A dose of 40 mJ/cm2 (312 nm) led to a decrease of both normal and tumor cells viability in a post-exposure time dependent manner, the most statistically significant reduction being recorded at 24h post-exposure. Moreover, some changes in the shape of cells exposed to UVB were detected. Our results confirm the cytotoxic effects associated with UVB exposure and could be further employed to evaluate the photo-protective effects of different agents.
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