Abstract
Background Panallergens (profilins, polcalcins and non-specific lipid transfer proteins) are responsible for polysensitization to various allergens including pollen and food allergens in a number of individuals which might account for a problem in distinguishing between true allergy from cross reactivity in allergy testing. A broad range of pollenand plant-derived allergens contain profilins and it has been shown in selected populations that 10% to 20% of patients with pollen allergy are sensitized to them. Patients with profilinspecific IgE antibodies in serum show higher risk of developing of the sensitization to multiple allergens.
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