Abstract
SINCE THE first reports detailing a new syndrome of dermatologic and ophthalmologic changes in patients receiving prolonged and high doses of chlorpromazine,<sup>1,2</sup>there have been many subsequent papers dealing with the subject.<sup>3-10</sup>Many of the reports have been concerned with the development of slate-blue skin pigmentation in these patients, and the general consensus has been that it is the result of a melanin or melaninlike substance. As previously reported, this syndrome is characterized by discoloration of the exposed areas of the body. The pigmentation may range in degree from a slight darkening of the skin to a definite slate-gray or blue color. Histologic examination has revealed a pigment chiefly in the corium, which has been suggested to be melanin. Ocular changes have been noted with and without overt skin pigmentation. The eye changes consist of a deposition of fine particles in the anterior capsular and subcapsular portion of
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