Abstract
Peripheral artery disease (PAD) is not only a serious complication but also a risk factor to predict prognosis in the patients with hemodialysis (HD). Ankle-brachial blood pressure index (ABI) has been widely used for detection of PAD. Skin perfusion pressure (SPP) was used for early detection of PAD by measurement of microcirculation of subcutaneous tissue. We studied the effectiveness of ABI and SPP to predict prognosis of HD patients. Both SPP and ABI were measured in 45 HD outpatients in Nagahara Hospital. The patients were followed with a mean observational period of 44.4 months to evaluate the association of ABI or SPP value with any-cause mortality. The median ABI and SPP values in all patients were 1.15 and 70.0 mmHg, respectively, and the patients were classified into two groups with the median value used as the cutoff points. In Kaplan-Meier analysis, the lower SPP group showed significantly worse survival curve than the higher SPP group while there were no differences between ABI groups. Cox proportional hazards model demonstrated SPP values are independent and significant risk factors for mortality. These results suggest evaluation of PAD by SPP measurement is useful to predict prognosis of HD patients.
Highlights
Peripheral artery disease (PAD) is a serious complication and a risk factor to predict prognosis in the patients with hemodialysis (HD)
This study is a retrospective analysis for 45 consecutive outpatient hemodialysis cases in Nagahara Hospital in November to December 2006 who were submitted to evaluation of the Ankle-brachial blood pressure index (ABI) and Skin perfusion pressure (SPP)
ABI and SPP have been used for the screening of PAD in the HD patients clinically [8, 10]
Summary
Peripheral artery disease (PAD) is a serious complication and a risk factor to predict prognosis in the patients with hemodialysis (HD). Ankle-brachial blood pressure index (ABI) has been widely used for detection of PAD. We studied the effectiveness of ABI and SPP to predict prognosis of HD patients. The frequent causes of death in the hemodialysis patients are heart failure and cardiovascular diseases [2]. The prevalence of heart disease and vascular disease is expected to rise with increased elderly patients, increased patients with diabetes mellitus, and increased long HD patients [3, 4]. Indicators should be required to predict heart failure and cardiovascular diseases in HD patients. Peripheral artery disease (PAD) is a common complication in the hemodialysis patients [5, 6].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
