Abstract
This study aimed to encapsulate Celastrus paniculatus seed oil (CPSO) in 2-hydroxypropyl-β-cyclodextrin (HPβCD) cavities and investigate their biological activity, physicochemical stability, and skin penetration by vertical Franz diffusion cells of the CPSO-HPβCD inclusion complex formulations. For biological activity studies-including 2,2-diphenyl-1-picryhydrazyl radical (DPPH) scavenging, metal ion chelating, and inhibition of lipid and tyrosinase inhibition activities-the CPSO-HPβCD inclusion complex exhibited lower inhibition activity than free CPSO. CPSO-HPβCD dispersion, serum, and gel formulations were prepared. All formulations containing the CPSO-HPβCD inclusion complex showed no significant changes in physical characteristics after three months' storage. The percentages of oleic acid remaining in all formulations were over 80% of the initial amount during a three-month stability study. For the skin-penetration study, compared to other formulations, the CPSO-HPβCD serum formulation exhibited the highest cumulative amount of oleic acid in the whole skin and flux through receptor fluid, after six hours, of 32.75 ± 1.25 µg/cm² and 1.02 ± 0.15 µg/cm²/h, respectively. The CPSO-HPβCD serum formulation also showed the proper viscosity. Hence, the CPSO-HPβCD inclusion complex will be beneficial for the further development of cosmeceutical products.
Highlights
Celastrus paniculatus is a member of the Celastraceae family, which is a large woody climber with a yellow corky bark [1]
The HPLC analysis showed that the Celastrus paniculatus seed oil (CPSO) in this study was mainly composed of cis-9-oleic acid (43.85% w/w)
The active constituents of CPSO have been reported in several studies, and it is composed of several fatty acids [21,22,23]
Summary
Celastrus paniculatus is a member of the Celastraceae family, which is a large woody climber (called a climbing shrub) with a yellow corky bark [1]. It is a native of the Indian continent but is known to grow wildly in Indonesia, Laos, Malaysia, Myanmar, and Thailand, as well as numerous Pacific islands [2]. In Northern Thailand, Celastrus paniculatus seed oil (CPSO) is used for massages with great benefits, for like muscle pain, paralysis, and joint stiffness from arthritis. Fatty acids, and especially oleic acid, have been reported for their antioxidant and anti-inflammatory activities [5,6], which may benefit topical skin applications. The oil is oxidized during storage and processing, which affects its quality, stability, and safety [8]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
