Abstract
The utilization of cosmetic raw materials for medicinal purposes in a microneedle patch containing hyaluronic acid (HA) and Lonicerae flos ethanol extract (LEE) has increased based on their eco-friendly characteristics. The moisturizing effects of this microneedle patch were assessed on the forearms of 20 female participants, and our results showed an increase between 29.60% and 88.54% in skin moisture content at the same time points relative to the untreated group. Apart from confirming the safety of HA and Lonicerae flos, our findings may also promote the use of HA and medicinal herbs in relevant industries, indicating their potential as raw ingredients for the development of cosmetic products and topical dermatological drugs. The results suggested that HA, Lonicerae flos, and other combinations of chemical and natural products based on traditional oriental medicine could beneficially affect skin health.
Highlights
Microneedle Patch ContainingRecently, there has been an increase in the development of cosmetics containing natural ingredients [1]
The results suggest that using the Hyaluronic acid (HA) microneedle patch with Lonicerae flos ethanol extract (LEE) soluble essence as well as a combination of skin moisturizing effects, based on the previously known moisturizing effect, have certain effects on skin health
Improvement in skin moisturizing was significantly higher with HA microneedle patch with LEE soluble essence (EG) than HA microneedle patch without LEE soluble essence (CG) after the application
Summary
Microneedle Patch ContainingRecently, there has been an increase in the development of cosmetics containing natural ingredients [1]. The number of beauty-related products containing clinically approved ingredients is gradually increasing [2]. Each cell in the human body contains a gene that synthesizes HA, and the known HA synthesis metabolic pathway includes hyaluronic acid synthase (HAS)-1, -2, -3, TGF-β (trans forming growth factor β), PDGF BB (platelet derived growth factor BB), FGF (fibroblast growth factor), and EGF (epidermal growth factor) [4]. Even though it is widely known that hyaluronic acid is closely related to the moisture condition of the skin, there are various medical limitations in injection of hyaluronic acid from outside the body, so if we consider solutions in promoting the synthesis of hyaluronic acid in human cells together, we can achieve a more effective moisturizing effect [5]. The increased demand for beauty products containing oriental medicine ingredients comes from social demands regarding ecofriendly concepts and the interest in K-beauty, based on Korean cultural content in the global market [7]
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