Abstract
Smmary Skin biopsies obtained from the hand have been evaluated by histological and histochemical techniques, in twenty patients with a confirmed diagnosis of chronic diffuse hepatopathies and in ten healthy controls. In patients with chronic hepatic disease, skin biopsies show microvascular lesions, characterized by thickening of the PAS-positive basement membrane and endothelial alterations, similar to those found in diabetic patients. These lesions did not exist in the healthy control group.
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