Abstract
Laser Doppler Fluxometry (LDF) was used to assess basic flow (PP) of microcirculation (mc) of dorsal hand skin in 10 healthy persons of both sex (k) – of age 41,3 ± 7,18 years and 10 persons suffering from primary arterial hypertension (nt) – of age 41,3 ± 10,95 years. In obtained record it has beed evaluated: basic flow (PP – in arbitray units of perfusion – PU) and, by analysing frequency spectrum – heart rhythm (RS) and its variation (ZRS), respiratory rhythm (RO), myogenic rhythm of precapillary sphincters tone (RM) and its amplitude (RMa), neurogenic rhythm of precapillary sphincters tone (RN) and its amplitude (NRa) and endothelium-dependent rhythm of precapillary sphincters tone (RE) and its amplitude (REa). The rhythm was assessed in cycles per minute (Hz) and the amplitude by value of signal power in arbitrary units. Means (x¯ ) and standard deviations (± SD) were defined; differences were assessed using t-Student test. In the group of individuals, suffering from arterial hypertension, the decrease of heart rhythm variability, acceleration of respiratory rhythm and neurogenic rhythm on the microcirculation level was observed, what testifies to higher sympathetic activity. In people with arterial hypertension such regularity was not observed, which can prove the endothelium dysfunction. LDF enables complex, noninvasive assessment of circulatory system functioning that can be widely used in clinical
Highlights
IntroductionComplex assessment of circulatory system functioning, including microcirculation (mc) is important element of planning and controlling both the effects of circulatory system diseases therapy, and planning and carrying out actions in the field of primary prophylaxis of those pathological states
Complex assessment of circulatory system functioning, including microcirculation is important element of planning and controlling both the effects of circulatory system diseases therapy, and planning and carrying out actions in the field of primary prophylaxis of those pathological states.In the course of arterial hypertension, at first, it comes to functional changes in mc that, with time, as the hypertension lasts through the stage of functional-structural changes, undergoes fixation.Laser Doppler Fluxometry is noninvasive method that, apart from local assessment of examined area of microcirculation, allows determining the heart rhythm and respiratory rhythm, indirectly assess functioning of vegetative nervous system on the level of heart labour and respiratory action and directly local functioning
The flow in dorsal hand skin microcirculation was examined with use of laser doppler fluxometry apparatus Periflux 4001 from the Perimed company, generating laser light of 632,8 μm wavelength
Summary
Complex assessment of circulatory system functioning, including microcirculation (mc) is important element of planning and controlling both the effects of circulatory system diseases therapy, and planning and carrying out actions in the field of primary prophylaxis of those pathological states. Laser Doppler Fluxometry is noninvasive method that, apart from local assessment of examined area of microcirculation, allows determining the heart rhythm and respiratory rhythm, indirectly assess functioning of vegetative nervous system on the level of heart labour and respiratory action and directly local functioning. The goal of this experiment was assessment of microcirculation function in arterial hypertension with regard to parameters of local function and parameters of heart labour and respiratory system, recorded on its level with use of noninvasive method – LDF
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