Skin microbiome in acne and role of dermatocosmetics in complex treatment (literature review)

Abstract

In acne, a microbial imbalance compared to a normal distribution in healthy tissues is thought to be involved in the pathophysiology of inflammatory acne. Extended metagenomic sequencing has shown that the skin microbiota of acne patients differs from the microbiota of people without acne at the level of a virulent-specific lineage. Acquired DNA sequences and bacterial immune elements may be involved in the virulence of C. acnes strains. Acne-associated strains produce significantly higher levels of pro-inflammatory metabolites, porphyrins, which generate reactive oxygen species and induce inflammation in keratinocytes. In light of these data, restoration of the skin microbiome in acne is one of the main goals of therapy. Specialized cosmetics that allow restoring skin microbiocenosis is a pathogenetically substantiated option for the complex treatment of patients with acne. To solve this problem, the scientists of the laboratory of La Roche-Posay have created an innovative range of products EFFACLAR H ISO-BIOME. The products effectively reduce all side effects caused by the use of topical and systemic drugs, and also normalize the skin microbiome by activating the growth of commensal microorganisms.