Abstract
BackgroundAlthough cervix carcinoma is one of the most common malignancies in women, hematogenous metastases are relatively not common. Cutaneous metastases, in particular, are unusual even at an advanced stage of disease. Their presence is a predictor of poor prognosis.Case presentationCase 1: A 63-year-old postmenopausal Moroccan woman was diagnosed as having cervical squamous cell carcinoma. She was treated with radical concurrent chemotherapy and radiation therapy followed by low-dose brachytherapy. Six months after finishing the therapy, multiple skin nodules appeared on her abdomen and chest wall. An excision biopsy was performed and showed metastatic squamous cell carcinoma. Her disease progressed and she died before completing her fourth course of palliative chemotherapy.Case 2: A 48-year-old Moroccan woman was diagnosed as having cervical squamous cell carcinoma; she was treated with concurrent chemoradiation. Before a planned high-dose brachytherapy, she noticed many nodular lesions on her arms, thighs, and chest wall. An excision biopsy was performed and showed metastatic squamous cell carcinoma. She then underwent a series of imaging examinations, including computed tomography of her chest, abdomen, and pelvis, and a whole body bone scan that showed disseminated disease involving her lungs and bones. She died after two courses of palliative chemotherapy, 2 months after the appearance of the skin lesions.ConclusionWe report two cases to illustrate a rare localization of metastasis from cervical carcinoma that is highly aggressive requiring early detection and aggressive management.
Highlights
BackgroundCarcinoma of the uterine cervix is the most common gynecological cancer in developing countries
Cervix carcinoma is one of the most common malignancies in women, hematogenous metastases are relatively not common
We report two cases to illustrate a rare localization of metastasis from cervical carcinoma that is highly aggressive requiring early detection and aggressive management
Summary
Carcinoma of the uterine cervix is the most common gynecological cancer in developing countries. A biopsy indicated squamous cell carcinoma moderately differentiated and keratinizing of her cervix Computed tomography of her chest, abdomen, and pelvis showed a cervical tumor of approximately 5 cm with hydroureteronephrosis. Benoulaid et al Journal of Medical Case Reports (2016) 10:265 metastasis She was staged as stage IIIB according to the International Federation of Gynecology and Obstetrics (FIGO) staging system. A cervical biopsy confirmed squamous cell carcinoma that was well differentiated and keratinizing histology Computed tomography of her chest, abdomen, and pelvis revealed a 5 cm cervical process extending up to the upper two-thirds of her vagina and the both parameters with multiple para-aortic and pelvic lymph nodes. Computed tomography of her chest, abdomen, and pelvis, and a whole body bone scan revealed multiple lung, liver, and bone metastases
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