Abstract
Emerging data indicates that melanoma may be linked to prostate cancer. We evaluated if the incidence of melanoma was associated with subsequent risk of prostate cancer (PC). We extracted data from the Lithuanian cancer registry from 1993 to 2012. We calculated the standardized incidence ratios (SIRs) for PC as a ratio of observed number of cancer cases in people with previous melanoma diagnosis to the expected number of cancer cases in the underlying general population. Therein, 95% confidence intervals for the SIRs were estimated assuming the number of observed cancer cases follows the Poisson distribution. Overall, 65 PCs were observed versus 52.5 expected (SIR 1.24; 95% CI: 0.97–1.58) within a period of 24 years. A significantly increased risk of PC was found in patients with melanoma diagnosis over 70 years (SIR 1.62; 95% CI: 1.11–2.39) and in two periods of diagnosis (SIRs 1.76 and 1.62 in 1993–1997 and 2009–2012, respectively). A significantly increased risk was also found five to nine years after melanoma diagnosis (SIR 1.58; 95% CI: 1.05–2.38). Further studies are needed to evaluate the relationship between melanoma and subsequent risk of prostate cancer.
Highlights
Melanoma is the most dangerous form of skin cancer and has an hypothesized association with androgens [1]
The cases were identified from the cancer registry based on the International Classification of Diseases 10th revision (ICD-10)
95% confidence intervals for the standardized incidence ratios (SIRs) were estimated assuming the number of observed cancer cases follows the Poisson distribution
Summary
Melanoma is the most dangerous form of skin cancer and has an hypothesized association with androgens [1]. Especially androgens, are involved in prostate cancer pathogenesis. A number of cancer registry-based epidemiological studies have reported an increased risk of prostate cancer in melanoma patients [2], as well as an increased risk of melanoma after an initial diagnosis of prostate cancer has been shown [3,4,5,6,7]. Both the biological mechanisms and detection biases have been proposed as explanations for the higher rates of melanoma in men with prostate cancer.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Environmental Research and Public Health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
