Abstract
Pregabalin is an antiepileptic drug that is analogous to gamma-aminobutyric acid and exhibits a structure similar to gabapentin. It has analgesic, anticonvulsant, anxiolytic and sleep-modulating properties in people ( Tassone et al., 2007 Tassone D.M. Boyce E. Guyer J. Nuzum D. Pregabalin: a novel gamma-aminobutyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders. Clin Ther. 2007; 29: 26-48 Abstract Full Text PDF PubMed Scopus (236) Google Scholar ). Pregabalin binds to the α2–δ subunit of calcium channels, resulting in a reduction in the release of several neurotransmitters, including glutamate, nor-adrenaline, serotonin, dopamine and substance P; it has been shown to be effective in neuropathic pain and is administered for the treatment of fibromyalgia, anxiety and as a sleep-modulating drug ( Gairai, 2007 Gairai N.M. Pregabalin: its pharmacology and use in pain management. Anesth Analg. 2007; 105: 1805-1815 Crossref PubMed Scopus (252) Google Scholar ).
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