Abstract
From roots of Peddiea volkensii (Thymelaeaceae) the irritant factors V 1 and V 2 and from roots of P. africana the irritant factor A 1 were isolated. Their structures are the 9,13,14- ortho-(2,4,6-decatrienoates) of 5β-hydroxyresiniferonol-6α,7α-oxide (V 1) and of 5β,12β-dihydroxyresiniferonol-6α,7α-oxide (A 1) and the 12- O-acetate of the latter (V 2). Factors V 1 and V 2 do not exhibit tumour-promoting activity in the standard initiation-promotion protocol on mouse skin, although V 1 is a moderate irritant.
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