Abstract
Skin health is a major concern across the world. The Paeonia lactiflora Pall. flower (PLPF) is well-known in China as an edible ornamental flower, that has been traditionally prescribed for the treatment of irregular menstruation and dysmenorrhea. However, its chemical constituents and bioactivities have not been systematically stuided. This study tentatively identified 27 compounds in aqueous and ethanol extracts of PLPF using ultra-performance liquid chromatography with quadrupole time-of-flight mass spectrometry, including four monoterpene glycosides, six phenols, six tannins, ten flavonoids and a hydroxycinnamic acid amide. Online antioxidant and tyrosinase inhibitor screening assays based on post-column bioactivity tests were used to screen for bioactive compounds in the extracts. Online and offline bioactivity assays showed that both extracts exhibited notable antioxidant properties against DPPH, ABTS, and FRAP, potent antiglycation capacity, and significant inhibition of tyrosinase, cyclooxygenase-2, and collagenase. Gallic acid derivatives were the main contributors to the antioxidant and antityrosinase capacity and may also inhibit cyclooxygenase-2 and collagenase, but they exhibited weak antiglycation capacity. The antiglycation effects may be due to the synergistic action of gallic acid and specific flavonoids. PLPF is a promising source of bioactive compounds for the development of natural skin health products.
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