Abstract
ABSTRACTPurpose:To evaluate whether using platelet-rich plasma (PRP) in the graft recipient bed after the resection of a neoplasia can influence its recurrence because this product stimulates angiogenesis, mitogenesis and chemotaxis.Methods:A study with 30 rats Wistar (Rattus norvegicus albinus), which were separated into group A (induction of carcinogenesis, PRP in the postoperative period) and group B (induction of carcinogenesis, absence of PRP in the postoperative period), with 15 animals in each. Carcinogenesis was induced on the skin of the animals’ chest by the topical application of 0.5% dimethylbenzantracene (DMBA) diluted in acetone. After surgical resection of the induced neoplasia, PRP was used to stimulate angiogenesis before surgical wound synthesis. Data on the control and experimental groups and macroscopic and microscopic variables were evaluated using analysis of variance and the Tukey’s test (5%).Results:It was possible to determine that the use of PRP is good in reconstructive surgeries, but it is contraindicated in patients during tumor resection, as it can cause changes in the surgical bed, in addition to stimulating recurrences and metastases.Conclusions:PRP may interact with tumour cells that were in the recipient site of the surgical wound during the resection of a neoplasia, and a local recurrence process can be triggered by applying this product.
Highlights
The growth of reconstructive surgery in veterinary medicine has occurred because of the increased survival of patients and owners seek the treatment and diagnosis of their animals’ diseases
platelet-rich plasma (PRP) may interact with tumour cells that were in the recipient site of the surgical wound during the resection of a neoplasia, and a local recurrence process can be triggered by applying this product
The surgical procedures of this study were conducted at Hospital Veterinário “Governador Laudo Natel”, Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP), School of Agricultural and Veterinarian Sciences, after evaluation and approval by the Ethics Committee on the Use of Animals (CEUA), with protocol number: 008102/17, in accordance with the rules issued by the National Council for the Control of Animal Experimentation (CONCEA)
Summary
The growth of reconstructive surgery in veterinary medicine has occurred because of the increased survival of patients and owners seek the treatment and diagnosis of their animals’ diseases. The grafts are deprived of arteries and veins in their constitution. They are impaired by necrosis after being implanted in a recipient bed[4]. Many studies report the effectiveness of PRP in healing when applied in reconstructive surgeries[5,6,7,8,9,10]. The efficacy of the use of PRP is proven through numerous studies. Whether this platelet-derived product could be used after resection of tumours has not been studied
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