Abstract
Collagen-based supplements have become a keystone in the management of the ageing process, with proven ability to repair skin damage, bestowing a youthful and healthy appearance sought in the pursuit of beauty. Collagen is an essential scaffold protein that gives smoothness and elasticity to skin, but its production declines with age. Finding ways to tackle this problem is now strongly promoted as an effective way to transform skin and hair, repairing age-related deterioration. A growing number of scientific studies show exciting evidence that it is possible to rejuvenate ageing or damaged skin, improve function of worn joints, and support personal wellbeing and vitality. In recent times, research on the mechanisms which impact the production of collagen in skin and the ideal organization into functional fibres which give skin its characteristic elasticity and firmness has provided new insights into how this bio-scaffold can support cells, tissues and organs. The factors which influence collagen production over a lifetime (e.g., puberty, pregnancy, menopause, andropause), intrinsic factors (e.g., genetics, age, ethnicity) and extrinsic factors (e.g., UV-radiation, pollution, smoking) and the potential for new technologies, ingredients and devices to restore collagen and matrix components to their optimal condition are improving the ability to deliver anti-aging strategies with unprecedented results. This paper will review skin collagen production, structure and function throughout the lifestages, emphasizing its relationship with health, appearance and beauty.
Highlights
Synthesis and structure of collagen in skinCollagen Synthesis by fibroblastsCollagen provides the support matrix/mattress underpinning healthy skin and is a key determinant to the preservation of skin firmness and elasticity[1,2]
Collagens are a diverse family of ubiquitous proteins with a wide range of cellular and extracellular functions, supporting cell signalling, proliferation, differentiation, and structural integrity of connective tissues
As the main protein found in the extracellular matrix of skin and bone, Type I collagen represents the most abundant collagen found in the body
Summary
Synthesis and structure of collagen in skinCollagen Synthesis by fibroblastsCollagen provides the support matrix/mattress underpinning healthy skin and is a key determinant to the preservation of skin firmness and elasticity[1,2]. This mechanism is key to the successful production of collagen reported in clinical studies following long term supplement use and the consequent reported improvement in skin elasticity and hydration.
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