Abstract
Skin care interventions in infants for preventing eczema and food allergy.
Highlights
There is no definitive cure for allergic disease, though there are treatments to alleviate symptoms
The burden of allergic disease on the individual, the family and society is significant (Gupta 2004; Pawankar 2014). The prevalence of such allergic diseases appears to have increased over the last few decades; traditionally this higher prevalence was seen in high-income countries, but there is an increasing prevalence of allergic diseases in urban cities of low- and middle-income countries (Deckers 2012; Prescott 2013)
Sharing clinical trials data is encouraged as best practice in clinical trials, and the sharing of individual participant data maximises knowledge gained from the e orts of trial participants (Taichman 2017)
Summary
Emollients can decrease water loss across the skin (TEWL), increase stratum corneum hydration, improve comfort, and reduce itch when used on skin that already has active eczema (Lodén 2012; Rawlings 2004), and are a key component of treatment of eczema (Ring 2012) They may be more e ective than interventions such as less frequent bathing, or water so eners, for eczema prevention. Preliminary data suggest that variations in infant skincare protection interventions, such as application of emollients, may influence risk of eczema or food sensitisation, at least during the intervention period (Horimukai 2014; Lowe 2018; Simpson 2014) This raises the possibility of a relatively simple, cheap and safe intervention to prevent two common and burdensome conditions. This review is important and timely, because ongoing clinical trials are formally testing the hypothesis that variations in infant skin care can influence risk of eczema or food allergy. Sharing clinical trials data is encouraged as best practice in clinical trials, and the sharing of individual participant data maximises knowledge gained from the e orts of trial participants (Taichman 2017)
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