Abstract
As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. With intrinsic aging, structural changes occur in the skin as a natural consequence of the biological changes over time and produce a certain number of histological, physiological, and biochemical modifications. Intrinsic aging is determined genetically (influence of gender and ethnic group), variable in function of skin site, and also influenced by hormonal changes. Visually it is characterized by fine wrinkles. By comparison, “photoaging” is the term used to describe the changes occurring in the skin, resulting from repetitive exposure to sunlight. The histological, physiological, and biochemical changes in the different layers of the skin are much more drastic. From a mechanical point of view, human skin appears as a layered composite containing the stiff thin cover layer presented by the stratum corneum, below which are the more compliant layers of viable epidermis and dermis and further below the much more compliant adjacent layer of subcutaneous white adipose tissue.
Highlights
Skin aging is a complex biological process influenced by a combination of endogenous or intrinsic and exogenous or extrinsic factors
By comparison, “photoaging” is the term used to describe the in daily donkey-milk baths, a practice which apparently changes occurring in the skin, resulting from repetitive required over 700 donkeys to accomplish
Aging can be viewed as the accumulation of changes in cells and tissues resulting from a greater disorderliness of regulatory mechanisms that result in reduced robustness of the organism to encountered stress and disease
Summary
Skin is the barrier that segregates the body from the outer environment. Besides protecting the body from water loss and microorganism infection, it has an important cosmetic role. Crème Céleste, a scientists, and researchers dedicated to the belief that the favorite product of empress Elisabeth (Sisi) of Austria, process of physical aging in humans can be slowed, stopped, or even reversed through existing medical and scientific interventions. Anti-aging medicine encompasses lifestyle changes (diet and exercise); hormone was a concoction of spermaceti (a wax found in the head of sperm whales), sweet almond oil, and rosewater. She would apply this daily and at night, she was known to coat her face in raw veal and crushed strawberries, kept in place with a custom-made leather mask. Global Journal of Medical Research ( BD) Volume XIX Issue II Version I Year 20 91
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