Skeletal Reorganization: Approaches Towards the Synthesis of Aza-heterocyclic Cores

Abstract

The impetuous development of the pharmaceutical industry and material science stimulates the search for new synthetic approaches and new methods for the synthesis and functionalization of aza-heterocycles; these are some of the key objectives of modern organic chemistry. As a result of such, advanced method towards the synthesis of functionalized N-heterocycle that circumvents the limitations associated with traditional methods need to be devised. In recent decades, rearrangement/ reorganization reactions have emerged as a powerful tool for the efficient synthesis of the aza-heterocycle. In this illustration , we summarize some our recent efforts in the development of few complex aza heterocyclic cores.