Skeletal Reorganization: Approaches towards the Synthesis of Aza-Heterocyclic Cores

Abstract

Listen

Translate article

AbstractThe impetuous development of the pharmaceutical industry and material science stimulates the search for new synthetic approaches and new methods for the synthesis and functionalization of aza-heterocycles; these are some of the key objectives of modern organic chemistry. As a result, an advanced method towards the synthesis of functionalized N-heterocycles that circumvents the limitations associated with traditional methods needs to be devised. In recent decades, rearrangement/reorganization reactions have emerged as a powerful tool for the efficient synthesis of the aza-heterocycle. In this illustration, we summarize some our recent efforts in the development of few complex aza-heterocyclic cores.1 Introduction2 Skeletal Rearrangement of Small Heterocycles via Domino Ring-Opening and Ring-Closing (DROC) Strategy3 Ru(II)-Catalyzed Skeletal Rearrangement of the Quinazoline Ring4 Lewis Acid Catalyzed Skeletal Rearrangement of Furans to Indolizine Cores5 Skeletal Rearrangement of Donor–Acceptor Cyclopropanes via Domino Ring-Opening and Ring-Closing (DROC) Strategy6 Lewis Acid Mediated Skeletal Rearrangement of Donor–Acceptor Spirocyclopropylpyrazolones7 Skeletal Rearrangement through Ring Distortion Strategy8 Conclusion