Abstract
Titin is a structural protein which provides the majority of passive force in striated muscle sarcomeres. Evidence using titin fragments or in isolated I-band titin suggests that titin contributes to mechanical work in shortening muscle at physiologically relevant lengths by quick refolding of previously unfolded immunoglobulin domains. Quick refolding of Ig-domains has not been observed in sarcomeres, so this study tested whether rapid refolding of unfolded titin Ig-domains is observable in sarcomeres.
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