Abstract
), during heightened metabolicdemand (i.e. contraction) there is anessential requirement for rapid andsustained ATP production, a role fulfilledprimarilybymitochondria.Assuch,skeletalmuscle cells are densely populated withthese complex organelles.Withanincreasingprevalenceofinactivityand obesity, type 2 diabetes has become amajor public health concern. Given theircentral role in energy production, it isperhaps not surprising that mitochondrialdysfunction has been implicated inthe aetiology of skeletal muscle insulinresistance, a precursor of frank diabetes.Furthermore,interventionswhichstimulateskeletal muscle mitochondrial biogenesiscan improve insulin sensitivity in obeseand/or insulin resistant individuals. Whileit seems clear that a reduction inskeletal muscle mitochondrial
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