Abstract
Exercise and fasting both increase free fatty acids, and elevated unsaturated free fatty acids are up‐regulators of lipid metabolism in skeletal muscles. We examined fatty acids in skeletal muscles in lines of Mus musculus artificially selected for high maximal metabolic rate (high‐MMR). These mice were not exercised and standard laboratory rat chow was available ad libitum. After 7 generations of directional selection for increased mass‐independent MMR, high‐MMR mice showed a 10.2% increase in mass‐independent MMR and a concomitant 2.8% increase in mass‐independent basal metabolic rate compared to control mice. Free fatty acids in the gastrocnemius muscle differed significantly between high‐MMR and control mice. For mice selected for high‐MMR, there was a significant increase in linoleic and oleic acids—consistent with elevated fatty acid oxidation in the skeletal muscle. There was no difference in muscle phospholipid fatty acid composition between high‐MMR and control mice. These findings suggest that selection for high‐MMR resulted in elevated fatty acid oxidation in the skeletal muscles. Most importantly, the results suggest that there is a genetic component to elevated unsaturated free fatty acids in skeletal muscles. Supported by NSF IOS 0344994.
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