Abstract
ABSTRACTObjectives: To provide an overview of the classic paradigm of physiology of skeletal muscle damage, inflammation, and repair mechanisms and to highlight some newer research in these areas.Findings: Skeletal muscle damage, inflammation, and repair, with some exceptions and regardless of the cause of damage, progress largely in the same way. This review highlights findings primarily from animal models augmented by selected human studies based mainly on the contraction-induced muscle damage model to outline the general paradigms of muscle damage and repair, as well as muscle soreness mechanisms. Newer research related to the regulation and implications of post-damage neutrophil infiltration, potential effects of specific drug-related interventions on muscle repair, and influence of sex steroid hormones and their loss in older adults on muscle repair potential are also highlighted.Conclusions: Ongoing research continues to refine our understanding of muscle repair regulation and will assist in refinin...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
