Abstract
Serotonin (5-HT) seems to be essential to mammal life, however, its various actions have hither to been difficult to assess due to their complexity; further more, it is not until the last few years that serotonin receptors have been typed and subtyped. Following this recent development of selective and pure serotonin receptor antagonists, it has been shown that serotonin is involved in the modulation of tissue blood flow and oxygenation in response to various stimuli. Hyperoxemia is known to cause arteriolar vasoconstriction, the disturbed tissue oxygenation and capillary flow in skeletal muscle can be normalized by ketanserin or ritanserin, 5-HT2 receptor antagonists (1,2). The purpose of the present study was to assess skeletal muscle capillary flow and oxygenation during hypoxic hypoxemia with particular reference to the action of 5-HT2 receptors.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
