Skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA) in rats

Abstract

A single administration of 3-thiadicarboxylic and tetradecylthioacetic acids stimulates both mitochondrial and peroxisomal β-oxidation and lowers plasma triacylglycerol levels. An increased rate of mitochondrial β-oxidation and carnitine palmitoyltransferase activity was established after 3 h and this was accompanied by a lowering of plasma triacylglycerol. Peroxisomal β-oxidation, however, remained unchanged up to 8 h and was significantly increased after 12 h. These results suggest that after a single administration of 3-thia fatty acids mitochondrial β-oxidation precedes peroxisomal β-oxidation. Furthermore, they show that the observed triacylglycerol-lowering effect, which is established early (3–4 h) after the administration of 3-thia fatty acids, is initially due to an increased mitochondrial β-oxidation.