Abstract

Estrogens clearly have beneficial effects on the skeleton of postmenopausal women. The development of the agents that act like estrogens in the skeleton but may have a different pattern of effect in other tissues, suggests the possibility that tissue-selective estrogens may become important in the management of post-menopausal women in the future, especially those who may be at risk of osteoporosis. Greater understanding of the action of these tissue-selective estrogens will allow the development of a novel compound with profiles that may target more definitively the needs of the postmenopausal population.

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