Abstract
Objectives. Long-term administration of bisphosphonates has been associated with bisphosphonate-related jaw osteonecrosis (ONJ). A potential etiologic factor is disproportionate concentration of bisphosphonate in the jaws, but it is unclear if regional biodistribution and bioavailability of bisphosphonates is site-dependent. We tested in rats the hypothesis that skeletal biodistribution and release of pamidronate (a nitrogen-containing bisphosphonate) is anatomic site-dependent.
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