Size of low‑density lipoprotein particles in patients after stroke

Abstract

30 Introduction Acute stroke is a severe clinical man‑ ifestation of atherothrombosis. Atherothrombo‑ sis and its complications are currently the most frequent cause of morbidity in the world. The ma‑ jor factors contributing to accelerated athero‑ thrombosis in humans are dyslipoproteinemias and hypertension, among others. The presence of atherogenic lipoproteins in plasma leads to the development of endothelial dysfunction, in‑ creases the vessel tone, and contributes to further deterioration of cerebral perfusion leading to ce‑ rebral ischemia. The aim of the present study was to evaluate atherogenic lipoproteins in patients with acute ischemic stroke admitted to the in‑ tensive care unit. Patients and methods We followed up 50 con‑ secutive patients with acute ischemic stroke (24 men and 26 women), aged from 35 to 90 years (mean age, 77.5 years ±11.8 years), and admit‑ ted to the 2nd Department of Internal Medicine of the Comenius University in Bratislava, Slo‑ vakia. The diagnosis of stroke was confirmed by a neurologist and by computed tomography. Af‑ ter admission, blood samples from the cubital vein were collected to measure routine biochem‑ ical parameters, including complete lipid profile