Size-effect of gold nanorods on modulating the kinetic process of amyloid-β aggregation

Abstract

Inhibiting the Aβ aggregation and understanding the kinetic process of Aβ fibrillation are very important for exploring possible tactics to treat AD. Here size-effect of Au NRs are reported to modulate the process of Aβ fibrillation. The results indicate that CTAB-stabilized Au NRs could efficiently suppress Aβ fibrillation and the inhibition efficiency of larger Au NRs is better. We calculated the relationship between Aβ aggregation rates and the sizes of Au NRs and found that the rate constant k was a quadratic function of diameters or lengths. This work provides a new strategy for exploring size-effect of nanoparticles on Aβ fibrillation.