Abstract
AbstractAn automated microscopic system was used to detect particulates from four different large-volume parenteral solutions in glass and plastic containers. Solutions from glass containers were found to contain a significantly greater number of particles; however, the mean diameter of particles from plastic containers was greater. Characteristics of the size distribution of particles from glass and plastic containers were also different. An overall (particle size 5-50μ) cleanliness factor was calculated. Cleanliness factors for glass containers were larger by 55.5% to 264.1% than those for plastic.
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