Abstract
Hydroayapatite (HAp) nanorods were widely used in biomedical fields such as multifunctional drug delivery systems, bone tissue damages and for dental applications. Here, rod shaped HAp nanoparticles with uniform morphology and controllable size were successfully synthesized without any templates by hydrothermal method. Powder X-Ray diffractometer (XRD), Optical Micrographs (OM), Nitrogen adsorption and desorption studies (BET), Field Emission Scanning Electron Microscope (FE-SEM) and Transmission Electron Microscope (TEM) were used to characterize the structure and composition of the prepared HAp samples. The biocompatibility of the prepared nanorods was tested against MG 63 human osteosarcoma cell lines using MTT assay. The results confirmed that the synthesized HAp nanorods are biocompatible, high purity in nature and high aspect ratio with mean width of 10 nm and mean length of 100 nm. Thus the prepared hydroayapatite nanorods can be used as drug carrying vehicles for hard tissue repair, bone regeneration, bone tissue engineering applications and as strength-enhancing additives for the preparation of biocompatible nanocomposites with improved mechanical properties.
Highlights
Calcium phosphates with Ca/P ratio between 1.5-2.0 belongs to the group of bioactive inorganics
The synthesis of HAp with controlled particle size and shape is important in order to improve the contact and stability at the natural bone interface [5].There are many methods developed for synthesizing of hydroxyapatite
We focused on the synthesis of HAp nanorods that resemble bone minerals with narrow size distribution
Summary
Calcium phosphates with Ca/P ratio between 1.5-2.0 belongs to the group of bioactive inorganics. It has the ability to form chemical bonding with bone tissue during in vivo conditions and to conduct bone tissue growth on the implanted materials [3].The important properties such as bioactivity, biocompatibility, stability and mechanical properties of HAp are determined by its crystal shape, size, composition and structure [4]. The synthesis of HAp with controlled particle size and shape is important in order to improve the contact and stability at the natural bone interface [5].There are many methods developed for synthesizing of hydroxyapatite. HAp nanorods were prepared using different organic surfactant or templates in order to manipulate crystal growth [10,11,12,13,14,15,16,17]. The HAp nanorods can be used for various biomedical aplications
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