Abstract
This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).
Highlights
A fundamental question in developmental biology is how different organs acquire their proper sizes, which are necessary for their healthy function
We find that fluid accumulation creates hydrostatic pressure in the lumen leading to stress in the epithelium and expansion of the otic vesicle
We show that fluid transports creates hydrostatic pressure in the lumen that drives growth, while negative feedback between pressure and fluid flux ensures control of organ size
Summary
A fundamental question in developmental biology is how different organs acquire their proper sizes, which are necessary for their healthy function. Classical organ transplantation and regeneration studies in the fly (Bryant and Levinson, 1985; Hariharan, 2015), mouse (Metcalf, 1963; Metcalf, 1964), and salamander (Twitty and Schwind, 1931) have indicated that both organ-autonomous and non-autonomous mechanisms control size. In his ”chalone” model, Bullough’s proposed growth duration to be regulated by an inhibitor of proliferation that is secreted by the growing organ and upon crossing a concentration threshold stops organ growth at the target size (Bullough and Laurence, 1964). Several studies have demonstrated that genetic mutation in these pathways is sufficient to alter organ or body size through increases in cell number, cell size, or both (Tumaneng et al, 2012), but the mechanisms that control size in the engineering sense (e.g. feedback of size on growth rate) are generally not known
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