Abstract
Ferrimagnetic nanoparticles have been limited in <i>in vivo</i> application because nanoparticles aggregate due to its remanent magnetization. Uniform-sized ferromagnetic iron oxide nanocubes with similar value of bulk saturated magnetization were synthesized. Control of nanocubes’ size minimized their remanence. PEG-phospholipid encapsulation enabled spacing to prevent the aggregation. As a result, water-dispersed single core ferrimagnetic iron oxide nanocubes were successfully prepared and their r<sub>2</sub> relaxivity was 761 s<sup>-1</sup>mM<sup>-1</sup>. It was very close to theoretical calculated value 800 s<sup>-1</sup>mM<sup>-1</sup> in static dephasing regime. in vivo MR images were obtained after intravenous injection of 22 nm nanoparticles to a mouse. The MR signal of tumor site changed significantly. In this research, synthesized ferrimagnetic iron oxide nanocubes showed a superior T2 contrast effect and it would be able to improve the quality of early diagnosis and detection of tumor.
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