Abstract
The number and sizes of blood platelets, the blood volume, and the sizes and ploidies of megakaryocytes were measured in New Zealand white rabbits that were hypercholesterolaemic as a result of a high cholesterol diet (0.5% cholesterol + 2% peanut oil) that was continued for as long as 19 weeks. Mean platelet volumes were lower than normal, but platelet counts, platelet mass/μl of blood, and blood volumes were normal. The ploidy distribution of megakaryocytes was normal, with 32N being the predominant ploidy group in both hyper- and normocholesterolaemic animals. The average sizes of all mature megakaryocytes and of those within the 16N ploidy group were less than normal. These findings suggest that hyperlipidaemia somehow limits the expansion of megakaryocyte cytoplasm and causes it to fragment into platelets of smaller than normal size.
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