Siyatik Sinir Gelişimi Esnasında Görülen Morfolojik Değişimlerin Sıçan Model Üzerinde Araştırılması: Histolojik, Stereolojik ve Embriyolojik Bir Çalışma

Abstract

Summary Myelinated axon numbers of the sciatic nerves which were obtained from 16 and 20 days foetuses, newborn and 5 weeks ages rats were estimated in this study.. In all groups gender factor was not considered. Following induction of anaesthesia, the sciatic nerves were removed and myelinated axon numbers were estimated. Sciatic nerve samples were also histologically analyzed. Overall, there was a 249% increase in the total number of myelinated axons in the sciatic nerves obtained from 20 days rat foetuses as compare to 16 days foetuses. Axon number in sciatic nerves got from newborn rats was decreased 56% as compare to twenty days foetuses. Histological results in this study were parallel to our stereological results. There were more myelinated axons in 20 days foetuses than in 16 days foetuses. It was also detected lesser myelinated nerve in sections obtained from newborn sciatic nerve than to 20 days foetuses. Moreover; the most myelinated axon number was observed in sciatic nerve got from 5 weeks ages adult rats. In view of these results, this study indicated that myelinated axons were decreased in the last a few days of pregnancy as compare to newborn group, whereas myelinated axon numbers were increased during postnatal ages till 5 weeks adult ages.