Abstract
Aralia chinensis var. dasyphylloides is widely distributed in China and used as a traditional herbal medicine for the treatment of digestive and immune system diseases. The present study aimed to search for novel oleanolic-type triterpenoids in low-polarity fractions. Six new triterpene derivatives (1–6), together with two known compounds were isolated from the barks of A. chinensis var. dasyphylloides. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analysis and chemical methods. They were identified as 3-oxo-oleana-11,13(18)-dien-28,30-dioic acid (1), 30-hydroxy-3-oxo-oleana-11,13(18)-dien-28-oic acid (2), 3β-hydroxy-oleana-11,13(18)-dien-28-oic acid-28-O-β-d-glucopyranoside (3), 3β,30-dihydroxy-oleana-11,13(18)-dien-28-oic acid-28-O-β-d-glucopyranoside (4), 3β-hydroxy-oleana-11,13(18)-dien-28-oic acid-3-O-β-d-xylopyranosyl-(1 → 2)-β-d-glucopyranoside (5), 3β,29-dihydroxy-oleana-9(11),12-dien-28-oic acid-28-O-β-d-glucopyranoside (6), namely, araliachinolic acids I and II and araliachinosides I–IV. The cytotoxicity of the isolated compounds was tested against HepG2, A549, SGC7901, and MCF7 cell lines, but no apparent activity was observed at a concentration of 50 μM.
Highlights
Previous phytochemical investigations on this plant revealed the presence of essential oil [2] and oleanolic-type triterpenoid saponins [3,4]
As part of our effort to search for novel oleanolic-type triterpenoids from A. chinensis var
The EtOH extract of the barks of A. chinensis var. dasyphylloides was fractionated by repeated medium-pressure (MPLC) var
Summary
(Araliaceae) is distributed in the Sichuan, Guizhou, Guangxi, and Hubei provinces of China [1]. Previous phytochemical investigations on this plant revealed the presence of essential oil [2] and oleanolic-type triterpenoid saponins [3,4]. Those saponins demonstrated inhibitory activities against α-glucosidase [5], moderate antioxidant effects and antiglycation activities [6], and cytotoxic activities against human nasopharyngeal carcinoma epithelial (CNE) cells [7]. As part of our effort to search for novel oleanolic-type triterpenoids from A. chinensis var. Dasyphylloides, we report here the isolation and structure determination of the new terpenoids.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
