Six new dammarane-type triterpene saponins from the processed leaves of Panax notoginseng

Abstract

Six new dammarane-type triterpenoid saponins, notoginsenosides SFt 5 –SFt 10 ( 1 – 6 ) were isolated from the processed leaves of Panax notoginseng (Burk.) F.H.Chen (Araliaceae), together with eight known notoginsenosides ( 7 – 14 ), fourteen known ginsenosides ( 15 − 28 ), two known vinaginsenosides ( 29 − 30 ), and one known gypenoside ( 31 ). Their structures were established by detailed spectroscopic analysis (NMR, UV, IR, HRESI-MS) and acidic hydrolysis. Four compounds notoginsenoside SFt 1 ( 7 ), ginsenosides Rg 5 ( 17 ), C-Mc ( 23 ) and 20( R )–Rg 3 ( 25 ) have significant protective effects against L -glutamate-induced SH–SY5Y nerve injury (10 μ M). • Six new triterpenoid saponins were isolated from Panax notoginseng. • Their structures were established by detailed spectroscopic analyses and acidic hydrolysis. • Four compounds demonstrated significant protective effects against L -glutamate-induced SH–SY5Y nerve injury.