Abstract
A diketone-based tridentate Schiff base, 3-[(2-hydroxyphenyl)amino]-1,3-diphenylprop-2-en-1-one (H2L), and its oxo-vanadium(V) dimer complex, [VO(L)(OMe)]2, were synthesized and characterized using spectroscopic and physicochemical techniques. Single crystal X-ray diffraction indicated that the Schiff base ligand in its deprotonated form was found to bind to the V(V) ion through the azomethine nitrogen, amine and phenolic oxygens in a distorted octahedral geometry. The other positions around the V(V) center were occupied by an oxido group and two oxygens from methoxido ligands. Antimicrobial studies showed that the synthesized complex indicated significant antimicrobial activities against Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 33591 and 29213) bacteria while no antibacterial activity was observed for the ligand alone. The potential of [VO(L)(OMe)]2 as an antimicrobial agent, was additionally investigated using molecular docking of the complex with GlcN-6-P synthase.
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