Abstract
To identify the characteristics indicative of involvement of occult tumors in the remnant breast on breast conservative surgery, we clinicopathologically examined the breast tumors and tissues surrounding the tumors in unilateral breast cancer with gross multiple tumors at the surgical specimen. Gross multiple tumor was found in 6 out of 98 cases of primary breast cancer (6.1%). Of these 6 cases, 5 cases (83.3%) were classified as intraductal spreading type, 1 case (16.7%) as multicentric type, and none as intramammary metastatic type. Histological type of 5 cases showing intraductal spreading type was either non-invasive intraductal cracinona or papillotubular carcinoma, and in 2 cases of them, component of comedo was found. Additionally, in the tissues surrounding tumors, benign breast diseases were found in 3 cases (50.0%), including atypical hyperplasia in 2 cases. We think that it is useful to know the degree of intraductal spreading, histological type of tumors, existence of comedo component and pathological features of tissues surrounding the tumors for predicting the existence of the occult tumors in the remnant breast on breast conservative surgery.
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