Site-Selective Remote Protoboration by Fe Catalysis

Abstract

Transition metal-catalyzed alkene hydro- or protoboration enables the regioselective incorporation of synthetically useful boryl groups within a molecule. However, selective borylation at less-activated positions distant from the initial reactive site within a molecule remains a challenge in chemistry. Recently, our group has demonstrated that an iron(II)-based complex can facilitate efficient borylations at typically less-reactive positions vicinal (β) to common functionalities through tandem alkene isomerization followed by protoboration.