Abstract
Accurate and low-cost methods of genotyping of single nucleotide polymorphism (SNP) caused by single base-pair substitution are crucially important for prediction of hereditary diseases, design of individualized medicine, and prognosis of SNP-related diseases. 1 For example, drug resistance in leukemia is often caused by several point mutations occurred in the leukemogenic gene. Such point mutations that constitute drug-resistant SNPs in chronic myelogenous leukemia (CML) include the T315I mutant, in which threonine (T) at position 315 is replaced with isoleucine (I) due to a single base change (C to U) in the ABL gene. 2
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