Abstract
The site of action of the crinkled ( cr) locus was determined by combining dermis and epidermis from the tail of 15-day + cr and cr cr mice and by growing the recombined skins in the testes of histocompatible mice. Since cr cr mice have bald tails, the presence or absence of hair in the graft was the feature used to determine gene action. Grafts of the combinations + cr epidermis- + cr dermis and + cr epidermis- cr cr dermis grew hair, whereas grafts of the combinations cr cr epidermis- + cr dermis and cr cr epidermis- cr cr dermis produced no hair. It was concluded that the cr locus, at least for tail skin, is active in the epidermis.
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