Abstract
The success rate of low-intensity pulsed ultrasound (LIPUS) therapy depends on the bone site. However, the initial mechanism of physical stimulation by ultrasound and bone cellular response remains unclear. One possible physical stimulation is the induced electrical potentials due to the piezoelectricity. In this study, the output electrical potentials of ultrasound transducers made from bovine bones were investigated. Transducers made from the radius bone showed the largest electric potentials, followed by tibia, femur, and humerus. There was clear site dependence of the induced electric potentials of bone, in good accordance with the success rate of LIPUS therapy.
Highlights
Low-intensity pulsed ultrasound (LIPUS) has attracted attention as a technique for healing bone fractures.1,2 This technique typically uses pulsed ultrasound from 1.5 to 3.0 MHz and shortens the healing time of bone fractures
Since the transducer output is the sum of all responses to the propagating wave in the surface electrode, the observed wave electrical potential depends on the receiver diameter
Regarding bone as a piezoelectric material, we examined the site dependence of ultrasonically induced electric potentials in bone
Summary
Low-intensity pulsed ultrasound (LIPUS) has attracted attention as a technique for healing bone fractures. This technique typically uses pulsed ultrasound from 1.5 to 3.0 MHz and shortens the healing time of bone fractures. Low-intensity pulsed ultrasound (LIPUS) has attracted attention as a technique for healing bone fractures.. Many clinical studies of LIPUS have been reported, the initial mechanism of physical stimulation by ultrasound and bone cellular response has not yet been elucidated.. Fukada and Yasuda reported that electrical potentials were generated inside bones when low-frequency mechanical stress in the kHz range was applied. Yasuda reported the formation of callus by applying a very small current of 1 lA using a 1.5 V battery to the femur of a rabbit. These induced electrical potentials promote bone growth and regeneration.. The piezoelectricity in the MHz range may concern the initial mechanism of bone fracture healing with ultrasound. To measure very smallmagnitude piezoelectricity in bone, we have fabricated ultrasound transducers using bones as piezoelectric materials have been fabricated, and their piezoelectric properties were confirmed in the MHz range. Ikushima et al. investigated stress-induced polarization in soft biological tissues by detecting the first harmonic component of the acoustically induced electric fields
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