Abstract
A lymphocyte culture system was used to study the frequency of chromosomal aberrations and SCEs at various time intervals after an international injection of apholate (0.5 mg/kg b.w.) in male albino rats. Treatment with apholate increased the frequency of chromosomal aberrations significantly ( P<0.001). The majority of chromosomal aberrations were single chromatid breaks, although other aberrations were also present. The distribution of chromatid breaks was non-random and the large chromosomes were affected to a greater extent. SCEs frequency in lymphocytes of apholate-treated rats was more than 5-fold higher in comparison to controls. The highest number of chromosomal aberrations and SCEs/rat was recorded at 48 h post-treatment, after which there was a gradual decline in both SCE and chromosomal aberration frequency. The results indicate that apholate is a mutagenic compound and it may also be carcinogenic.
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