Abstract

Sister Mary Joseph Nodule is an eponymous term referring to an umbilical nodule harbouring malignant metastatic cancer. It is a physical finding that is uncommon yet significant since it indicates the late manifestation of a variety of deep-seated abdominopelvic malignancies. This review article briefly revisits the historical background, epidemiology, anatomical routes of metastasis, clinical presentation, differential diagnosis, diagnostic work-up, clinical significance and prognosis of Sister Mary Joseph’s nodule.

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